Student Profiles: Students | Alumni | All Arta Monjazeb, MD, PhD Brielle Paolini Chris Starr, PhD Chris Lack, MD, PhD Christopher T. Whitlow, MD, PhD Dino Massoglia, MD, PhD Eric Hudgins, PhD Greg Riedlinger, MD, PhD Isabel Newton, MD, PhD Jason Hipp, MD, PhD Jason Bonomo Jenn Martelle, MD, PhD Jennifer Hipp, PhD Kim Blish, PhD Kristin Dew Weimer Kyle Binder Lan Gardner Coffman, MD, PhD Matt Schindler, MD, PhD Mitchell Ladd Nanmeng Yu Oleg Lobanov Rebecca Myer, MD, PhD Sandy An Walter Wiggins

Jenn Martelle, MD, PhD

Cocaine is a highly addictive substance with dangerous side effects ranging from lethal cardiovascular events to severe quality-of-life decline; it is also one of the most commonly abused substances today. My research interests involve the neurochemical and behavioral effects of cocaine abuse, in particular, the role of the dopamine D3 receptor in propagating specific drug effects. Using drug discrimination and progressive-ratio self-administration techniques, we can examine the relationships between cocaine dose, relative reinforcing strength, the production of discriminitive stimuli, and the response to treatment with D3 partial-agonists. By examining these relationships at the level of the individual, we hope to gain a better understanding of dopamine receptor mechanisms important to cocaine's abuse liability. Understanding the behavioral and neurochemical mechanisms that mediate cocaine reinforcement and exploring how individual differences may dictate responses to various pharmacotherapies will move the drug abuse field closer to providing effective, targeted treatment strategies able to combat cocaine dependence.

Abstracts:

Martelle JL, Nader MA (2007). The reinforcing and discriminative stimulus effects of self-administered cocaine in rhesus monkeys: a within-subject design. NIDA early career investigator poster session at Annual Meeting of the American Psychological Association. San Francisco, CA

Martelle JL, Czoty PW, Nader MA (2007). Chronic d-amphetamine treatment attenuates the reinforcing strength of cocaine in rhesus monkeys. Annual Meeting of American Society for Pharmacology and Experimental Therapeutics, Experimental Biology. Washington, DC

Martelle JL, Nader MA, Newman AH (2006). The use of human and animal models to better understand the role of dopamine in cocaine abuse: an historical review and implications for future pharmacotherapies. Annual Meeting of the Society for Neuroscience. Atlanta, GA

Martelle JL, Claytor R, Ross J, Newman AH, Nader MA (2006). Effects of two novel D3-selective compounds, NGB 2904 and CJB 090, on the reinforcing and discriminative stimulus effects of cocaine in rhesus monkeys. Annual Meeting of the American Physician Scientist Association. Chicago, IL

Martelle JL, Ross JT, Newman AH, Nader MA (2005) Effects of novel D3 compounds NGB 2904 and CJB 090 in monkeys trained to discriminate cocaine. Annual Meeting of the College on Problems of Drug Dependence. Orlando, FL

Presentations/Seminars:

Martelle JL (2007) The reinforcing and discriminative stimulus effects of self-administered cocaine: a within subject design. Wake Forest - Emory Lab Exchange. Atlanta, GA

Martelle JL (2007). A novel model of cocaine abuse: examining the interactions between discriminative stimulus and reinforcing effects in monkeys. Department of Physiology and Pharmacology Graduate Student Seminar Series. Winston-Salem, NC.

Martelle JL (2006). D3 receptors in primate models of cocaine abuse. Annual Meeting of the Society for Neuroscience. Atlanta, GA

Martelle JL (2006) Reinventing the Wheel: Relating Discrimination to Reinforcement. Wake Forest - Emory Lab Exchange. Winston Salem, NC

Martelle JL (2005) Cocaine dependence: searching for pharmacotherapies. Department of Physiology and Pharmacology Graduate Student Seminar Series. Winston-Salem, NC.

Martelle JL (2005) Cocaine discrimination: the effects of novel D3 compounds CJB 090 and NGB 2904. Wake Forest - Emory Lab Exchange. Atlanta, GA.

Martelle JL (2005) Cocaine discriminative stimulus effects: the role of novel D3 compounds CJB 090 and NGB 2904. Medical University of South Carolina-Wake Forest University CNIDA retreat. Cashiers, NC.

Teaching Experience:

Wake Forest University School of Medicine
Fall 2007 Physiology/Pharmacology I: Carbohydrates and Cell Energy, 1.5 hrs

Fall 2007 Physiology/Pharmacology I: Sugar Metabolism, 1.5 hrs

Spring 2007 Physiology/Pharmacology IV: Antibiotics, 1.5 hrs

Spring 2007 Physiology/Pharmacology IV: Antifungals, 1.5 hrs

Martelle JL*, Claytor R*, Ross J, Newman AH, Nader MA (2007). Effects of two novel D3-selective compounds, NGB 2904 and CJB 090, on the reinforcing and discriminative stimulus effects of cocaine in rhesus monkeys. J.Pharmacol.Exp.Ther. 321(2): 573-82. (*Both contributed equally).

Czoty PW, Martelle JL, Nader MA (2006). Influence of Abstinence and Conditions of Cocaine Access on the Reinforcing Strength of Cocaine in Nonhuman Primates. Drug and Alcohol Dependence 85: 213-20.

2007 Young Investigator Travel Award, NIDA Sponsored Poster Session, American
Psychological Association Annual Meeting

2007 Graduate Student Travel Award, American Society of Pharmacology and
Experimental Therapeutics Annual Meeting

2005-2006 Graduate Student Fellowship
Wake Forest University School of Medicine

2003-Present Academic Merit Award Recipient
Wake Forest University School of Medicine

2002 Noramco, Inc., a Johnson & Johnson affiliate, Student Internship
University of Georgia

2002 Delta Epsilon Iota National Honor Society Induction
University of Georgia

2001-2003 Presidential Scholar (4.0 GPA)
University of Georgia

2001 Alpha Epsilon Delta Premedical Honor Society Induction
University of Georgia

2000 Golden Key National Honor Society Induction
University of Georgia

2000 National Society of Collegiate Scholars Induction
University of Georgia

1999-2003 Honors Program Fellow
University of Georgia

2007-Present American Society for Pharmacology and Eperimental Therapeutics: Student

2006-Present American Society of Addiction Medicine: Student

2006-Present Society for Neuroscience: Student

2005-Present International Study Group Investigating Drugs As Reinforcers: Student

2005-Present College on Problems of Drug Dependence: Student

2004-Present American Medical Association: Student

2004-Present North Carolina Medical Society: Student

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